Overview
Butyrate prodrug for colonocytes.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Hydrolyzed to butyrate in intestine.
- · Hydrolyzed to butyrate in intestine
Effects on the body
Organ system effects
Tributyrin influences gut motility, mucosal integrity, or microbial balance in the GI tract.
Evidence-based benefits
Anti-inflammatory in colon
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Supplement interactions
- Multi-strain probioticSupports microbiome diversity and barrier integrity.
- L-glutamineSubstrate for enterocyte energy and tight-junction maintenance.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Tributyrin — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Tributyrin third party tested NSF
CapsulesPre-measured Tributyrin capsules — easiest for travel and consistent daily dosing without scoops or scales.Tributyrin capsules
PowderBulk unflavored Tributyrin powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Tributyrin powder unflavored
Best sellersMost-purchased Tributyrin products on Amazon — a quick way to see what's reviewed widely before you commit.Tributyrin best sellerScientific evidence8Show studiesHide studies
Sodium butyrate in IBD
Vernia P, et al.
Ulcerative colitis patients
Reduced inflammation markers.
PubMed: Tributyrin — Anti-inflammatory in colon
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PubMed: Tributyrin — randomized controlled trial
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PubMed: Tributyrin — meta-analysis
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PubMed: Tributyrin — safety adverse events
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PubMed: Tributyrin — dose response
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Google Scholar: Tributyrin — clinical evidence
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