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evidence · mechanism · dose
Supplements/Compound

Tributyrin

Butyrate prodrug for colonocytes.

Overview

Butyrate prodrug for colonocytes.

Natural sources
    Common forms

      Mechanism of action

      Hydrolyzed to butyrate in intestine.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Anti-inflammatory in colon

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            150–300 mg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Tributyrin
            Amazon
            Wide selection · fast shipping
            Compound
            Tributyrin
            iHerb
            Global delivery · curated brands
            Compound
            Tributyrin
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTEur Rev Med Pharmacol Sci · 2003

            Sodium butyrate in IBD

            Vernia P, et al.

            Ulcerative colitis patients

            Key findings

            Reduced inflammation markers.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Tributyrin — Anti-inflammatory in colon

            Live PubMed search

            Live results for "Tributyrin Anti-inflammatory in colon" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Tributyrin and "Anti-inflammatory in colon". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Tributyrin — randomized controlled trial

            Live PubMed search

            Live results for "Tributyrin randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Tributyrin and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Tributyrin — meta-analysis

            Live PubMed search

            Live results for "Tributyrin meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Tributyrin and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Tributyrin — pharmacokinetics

            Live PubMed search

            Live results for "Tributyrin pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Tributyrin and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Tributyrin — safety adverse events

            Live PubMed search

            Live results for "Tributyrin safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Tributyrin and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Tributyrin — dose response

            Live PubMed search

            Live results for "Tributyrin dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Tributyrin and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Tributyrin — clinical evidence

            Live Scholar search

            Cross-database citation index for Tributyrin as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.