Supplement Scholar
Fatty Acid

Borage Oil

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Borage Oil. Highest GLA content.

How it works. GLA converts to DGLA, anti-inflammatory.

What the research supports. 1 graded claims. Strongest: Improves RA symptoms (moderate).

How much to take. Typical dose: 1.4 g GLA.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Collagen peptides, Vitamin C.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Borage Oil. Anecdotes are not medical advice.

Borage Oil. Highest GLA content.

Key compound: gamma-linolenic acidC18H30O2 · 278.4 g/mol

What it is

Highest GLA content.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

Goals

Skin, Hair & Nails

How it works

GLA converts to DGLA, anti-inflammatory.

Pathways

  • GLA converts to DGLA, anti-inflammatory

Effects

  • +RA symptoms supports

What the research supports

Improves RA symptomsmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
1.4 g GLA
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodEither with or without food.
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • GI upset
  • PA contamination

Medication interactions

Prescription medications (general)minor

Always disclose Borage Oil use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Collagen peptidesProvides amino acid substrate for connective tissue synthesis.
  • Vitamin CRequired cofactor for collagen hydroxylation.

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: Borage Oil — Improves RA symptoms ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Borage Oil and "Improves RA symptoms". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Borage Oil — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Borage Oil and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Borage Oil — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Borage Oil and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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