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Compound

B. infantis 35624 (Align)

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B. infantis 35624 (Align). IBS-specific probiotic.

How it works. Anti-inflammatory immunomodulation.

What the research supports. 1 graded claims. Strongest: Reduces IBS symptoms (moderate).

How much to take. Typical dose: 1 billion CFU.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Multi-strain probiotic, L-glutamine.

Common forms. Available as Capsule or softgel, Powder, Sublingual or buccal, Liposomal liquid.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried B. infantis 35624 (Align). Anecdotes are not medical advice.

B. infantis 35624 (Align). IBS-specific probiotic.

No single structure

What it is

IBS-specific probiotic.

Food sources

Endogenously produced or biosynthesized moleculeStandardized pharmaceutical- or food-grade supplementCombined with cofactors that improve absorption or activity

How it works

Anti-inflammatory immunomodulation.

Pathways

  • Anti-inflammatory immunomodulation

Effects

  • ↓IBS symptoms decreases

What the research supports

Reduces IBS symptomsmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
1 billion CFU
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith a meal containing fat for fat-soluble compounds; otherwise either.
Best formMost evidence is based on the capsule or softgel form.
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Side effects & interactions

Common side effects

  • Bloating

Medication interactions

Prescription medications (general)minor

Always disclose B. infantis 35624 (Align) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

Common forms

  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Key studies

8 studies cited in total.

PubMed: B. infantis 35624 (Align) — Reduces IBS symptoms ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching B. infantis 35624 (Align) and "Reduces IBS symptoms". Filter by RCT, meta-analysis, or year on the results page.

PubMed: B. infantis 35624 (Align) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching B. infantis 35624 (Align) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: B. infantis 35624 (Align) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching B. infantis 35624 (Align) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

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