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evidence · mechanism · dose
Supplements/Compound

B. infantis 35624 (Align)

IBS-specific probiotic.

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Overview

IBS-specific probiotic.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

Anti-inflammatory immunomodulation.

Pathways
  • · Anti-inflammatory immunomodulation

Effects on the body

Decreases
IBS symptoms

Organ system effects

Digestive / Gut

B. infantis 35624 (Align) influences gut motility, mucosal integrity, or microbial balance in the GI tract.

Evidence-based benefits

Reduces IBS symptoms

Moderate evidence

Potential side effects

Common
  • · Bloating
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose B. infantis 35624 (Align) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • Multi-strain probiotic
        Supports microbiome diversity and barrier integrity.
      • L-glutamine
        Substrate for enterocyte energy and tight-junction maintenance.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      1 billion CFU
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      With a meal containing fat for fat-soluble compounds; otherwise either.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

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      Scientific evidence8Show studies
      RCTAm J Gastroenterol · 2006

      B. infantis in IBS

      Whorwell PJ, et al.

      362 women with IBS

      Key findings

      Improved global IBS symptoms.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: B. infantis 35624 (Align) — Reduces IBS symptoms

      Live PubMed search

      Live results for "B. infantis 35624 (Align) Reduces IBS symptoms" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching B. infantis 35624 (Align) and "Reduces IBS symptoms". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: B. infantis 35624 (Align) — randomized controlled trial

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      Live results for "B. infantis 35624 (Align) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

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      Opens current human and preclinical literature matching B. infantis 35624 (Align) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: B. infantis 35624 (Align) — meta-analysis

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      Opens current human and preclinical literature matching B. infantis 35624 (Align) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: B. infantis 35624 (Align) — pharmacokinetics

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      Live results for "B. infantis 35624 (Align) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

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      Systematic reviewPubMed (NLM) · 1970

      PubMed: B. infantis 35624 (Align) — safety adverse events

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      Systematic reviewPubMed (NLM) · 1970

      PubMed: B. infantis 35624 (Align) — dose response

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      Opens current human and preclinical literature matching B. infantis 35624 (Align) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: B. infantis 35624 (Align) — clinical evidence

      Live Scholar search

      Cross-database citation index for B. infantis 35624 (Align) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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