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evidence · mechanism · dose
Supplements/Compound

Berberine HCl

Quaternary alkaloid for glucose and lipid control.

Overview

Quaternary alkaloid for glucose and lipid control.

Natural sources
    Common forms

      Mechanism of action

      Activates AMPK and inhibits PCSK9.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Comparable to metformin for glucose

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        • · Bitter taste
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            500 mg TID

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            Berberine HCl
            Amazon
            Wide selection · fast shipping
            Compound
            Berberine HCl
            iHerb
            Global delivery · curated brands
            Compound
            Berberine HCl
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTMetabolism · 2008

            Berberine vs metformin

            Yin J, et al.

            T2DM patients

            Key findings

            Comparable HbA1c reduction.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Berberine HCl — Comparable to metformin for glucose

            Live PubMed search

            Live results for "Berberine HCl Comparable to metformin for glucose" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Berberine HCl and "Comparable to metformin for glucose". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Berberine HCl — randomized controlled trial

            Live PubMed search

            Live results for "Berberine HCl randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Berberine HCl and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Berberine HCl — meta-analysis

            Live PubMed search

            Live results for "Berberine HCl meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Berberine HCl and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Berberine HCl — pharmacokinetics

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            Live results for "Berberine HCl pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Berberine HCl and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Berberine HCl — safety adverse events

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            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Berberine HCl — dose response

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            Live results for "Berberine HCl dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Berberine HCl and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Berberine HCl — clinical evidence

            Live Scholar search

            Cross-database citation index for Berberine HCl as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.