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evidence · mechanism · dose
Supplements/Compound

ASU (Avocado-Soybean Unsaponifiables)

Standardized lipid extract slowing OA progression.

Overview

Standardized lipid extract slowing OA progression.

Natural sources
    Common forms

      Mechanism of action

      Inhibits IL-1β, MMPs, and stimulates TGF-β driven cartilage repair.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces NSAID use in hip and knee OA

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            300 mg/day (Piascledine)
            With food?
            With food

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            ASU (Avocado…
            Amazon
            Wide selection · fast shipping
            Compound
            ASU (Avocado…
            iHerb
            Global delivery · curated brands
            Compound
            ASU (Avocado…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTArthritis Rheum · 1998

            ASU in hip and knee OA

            Maheu E, et al.

            6-month DB-RCT in 164 hip OA patients.

            Key findings

            Significant reduction in NSAID use vs placebo.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: ASU (Avocado-Soybean Unsaponifiables) — Reduces NSAID use in hip and knee OA

            Live PubMed search

            Live results for "ASU (Avocado-Soybean Unsaponifiables) Reduces NSAID use in hip and knee OA" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching ASU (Avocado-Soybean Unsaponifiables) and "Reduces NSAID use in hip and knee OA". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: ASU (Avocado-Soybean Unsaponifiables) — randomized controlled trial

            Live PubMed search

            Live results for "ASU (Avocado-Soybean Unsaponifiables) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching ASU (Avocado-Soybean Unsaponifiables) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: ASU (Avocado-Soybean Unsaponifiables) — meta-analysis

            Live PubMed search

            Live results for "ASU (Avocado-Soybean Unsaponifiables) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching ASU (Avocado-Soybean Unsaponifiables) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: ASU (Avocado-Soybean Unsaponifiables) — pharmacokinetics

            Live PubMed search

            Live results for "ASU (Avocado-Soybean Unsaponifiables) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching ASU (Avocado-Soybean Unsaponifiables) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: ASU (Avocado-Soybean Unsaponifiables) — safety adverse events

            Live PubMed search

            Live results for "ASU (Avocado-Soybean Unsaponifiables) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching ASU (Avocado-Soybean Unsaponifiables) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: ASU (Avocado-Soybean Unsaponifiables) — dose response

            Live PubMed search

            Live results for "ASU (Avocado-Soybean Unsaponifiables) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching ASU (Avocado-Soybean Unsaponifiables) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: ASU (Avocado-Soybean Unsaponifiables) — clinical evidence

            Live Scholar search

            Cross-database citation index for ASU (Avocado-Soybean Unsaponifiables) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.