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Herb

Andrographis (KalmCold)

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Andrographis (KalmCold). Standardized andrographolide for acute upper respiratory infections.

How it works. Modulates NF-κB, cytokine release, and immune cell trafficking.

What the research supports. 1 graded claims. Strongest: Shortens URI duration (strong).

How much to take. Typical dose: 200 mg KalmCold.

Side effects and interactions. 2 medication interactions listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Vitamin D3 + K2, Zinc.

Common forms. Available as Standardized extract capsule, Liquid tincture (alcohol or glycerin), Powdered whole herb, Traditional decoction or tea.

Key studies. 8 studies cited. The strongest are listed with links to PubMed.

Community. Experiences from people who have tried Andrographis (KalmCold). Anecdotes are not medical advice.

Andrographis (KalmCold). Standardized andrographolide for acute upper respiratory infections.

Key compound: andrographolideC20H30O5 · 350.4 g/mol

What it is

Standardized andrographolide for acute upper respiratory infections.

Food sources

Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice

Goals

Immune Function

How it works

Modulates NF-κB, cytokine release, and immune cell trafficking.

Pathways

  • Modulates NF-κB, cytokine release
  • and immune cell trafficking

Effects

  • +Shortens URI duration supports

What the research supports

Shortens URI durationstrong

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Typical dose
200 mg KalmCold
TimingConsistent daily timing recommended; split larger doses if GI tolerance is a concern.
With foodWith food
Best formMost evidence is based on the standardized extract capsule form.
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Side effects & interactions

Common side effects

  • GI upset
  • Skin rash

Medication interactions

Anticoagulantsmoderate

Antiplatelet effect.

Immunosuppressantsmoderate

Antagonism.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Vitamin D3 + K2Foundational immune modulation.
  • ZincRequired cofactor for innate and adaptive immune function.

Common forms

  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Key studies

8 studies cited in total.

PubMed: Andrographis (KalmCold) — Shortens URI duration ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Andrographis (KalmCold) and "Shortens URI duration". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Andrographis (KalmCold) — randomized controlled trial ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Andrographis (KalmCold) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

PubMed: Andrographis (KalmCold) — meta-analysis ↗
Systematic review · PubMed (NLM) · 2026

Opens current human and preclinical literature matching Andrographis (KalmCold) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

Discussion

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