Supplement Scholar
Healing & Repair

TB-500

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

TB-500. A synthetic fragment of thymosin beta-4 studied for systemic tissue regeneration, vascular growth, and wound closure.

How it works. Binds and sequesters actin monomers, promoting cell migration, new blood-vessel formation, and reduction of inflammation at injury sites.

What the research supports. 3 graded claims. Strongest: Used in veterinary practice for racehorse soft-tissue recovery (preclinical).

Hormonal impact. Effects on Inflammatory cytokines (TNF-α, IL-6), IL-10 (anti-inflammatory), VEGF, Sex hormones / GH axis.

Side effects and interactions. 1 medication interaction listed. Serious: Long-term safety in humans is unknown.

Stacking. Pairs well with BPC-157. Avoid combining with Active cancer therapy.

Common forms. Available as Subcutaneous or intramuscular injection.

Community. Experiences from people who have tried TB-500. Anecdotes are not medical advice.

TB-500. A synthetic fragment of thymosin beta-4 studied for systemic tissue regeneration, vascular growth, and wound closure.

7-residue chainC38H68N10O14 · 889.0 g/mol

What it is

TB-500 is a synthetic peptide based on a region of the naturally occurring thymosin beta-4 protein, which regulates cell migration, blood-vessel formation, and tissue repair.

Also called

Thymosin Beta-4 fragment

How it works

Binds and sequesters actin monomers, promoting cell migration, new blood-vessel formation, and reduction of inflammation at injury sites.

Pathways

  • Actin regulation (G-actin sequestration)
  • Angiogenesis
  • Stem-cell migration to injury sites

Effects

  • ↑Cell migration toward injury increases
  • +Wound and tendon healing in animals supports
  • ↓Local inflammation decreases

What the research supports

Used in veterinary practice for racehorse soft-tissue recoverypreclinical
Anecdotal faster recovery from overuse injuriespreclinical
May improve flexibility and range of motion post-injurypreclinical

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Hormonal impact

↓Inflammatory cytokines (TNF-α, IL-6)decreases
↑IL-10 (anti-inflammatory)increases
↑VEGFincreases
=Sex hormones / GH axisstabilizes

Side effects & interactions

Common side effects

  • Injection-site reaction
  • Lethargy for 24–48 hours

Serious

  • Long-term safety in humans is unknown

Medication interactions

Immunosuppressantsmoderate

Theoretical interference with immune-mediated healing pathways.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • BPC-157Commonly paired for complementary repair effects in research protocols.

Avoid combining

  • Active cancer therapyAngiogenic and migratory signals may be inappropriate during treatment.

Common forms

  • Subcutaneous or intramuscular injection

Discussion

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