Setmelanotide
Also: Imcivree
MC4 receptor agonist approved for rare genetic forms of obesity.
What it is
Approved for obesity caused by POMC, PCSK1 or LEPR deficiency and for Bardet-Biedl syndrome. It is not a treatment for common obesity.
Common forms
How it works
Activates melanocortin-4 receptors in the hypothalamus, restoring the fullness signal that these gene defects break.
↓Hunger
↓Body weight (in eligible genetic conditions)
↑Skin pigmentation
What the research supports
Weight and hunger reduction in POMC or LEPR deficiencystrong
Weight reduction in Bardet-Biedl syndromemoderate
Side effects & interactions
Side effects
- Skin darkening
- Injection-site reactions
- Nausea
- Depression or suicidal thoughts (monitor) serious
- Unwanted erections serious
Medications
- No notable drug interactions listed.
Discussion
Experiences from people who have tried Setmelanotide. Anecdotes are not medical advice.
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