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Metabolic / Melanocortin

Setmelanotide

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

Setmelanotide. MC4 receptor agonist approved for rare genetic forms of obesity.

How it works. Activates melanocortin-4 receptors in the hypothalamus, restoring the fullness signal that these gene defects break.

What the research supports. 2 graded claims. Strongest: Weight and hunger reduction in POMC or LEPR deficiency (strong).

Side effects and interactions. 0 medication interactions listed. Serious: Depression or suicidal thoughts (monitor).

Common forms. Available as Daily injection.

Community. Experiences from people who have tried Setmelanotide. Anecdotes are not medical advice.

Setmelanotide. MC4 receptor agonist approved for rare genetic forms of obesity.

Molecular structureC49H68N18O9S2 · 1117.3 g/mol

What it is

Approved for obesity caused by POMC, PCSK1 or LEPR deficiency and for Bardet-Biedl syndrome. It is not a treatment for common obesity.

Also called

Imcivree

How it works

Activates melanocortin-4 receptors in the hypothalamus, restoring the fullness signal that these gene defects break.

Pathways

  • MC4 receptor agonism
  • Hypothalamic satiety signaling

Effects

  • ↓Hunger decreases
  • ↓Body weight (in eligible genetic conditions) decreases
  • ↑Skin pigmentation increases

What the research supports

Weight and hunger reduction in POMC or LEPR deficiencystrong
Weight reduction in Bardet-Biedl syndromemoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Side effects & interactions

Common side effects

  • Skin darkening
  • Injection-site reactions
  • Nausea

Serious

  • Depression or suicidal thoughts (monitor)
  • Unwanted erections

No notable medication interactions listed.

Check any supplement–medication combination with your pharmacist before starting.

Common forms

  • Daily injection

Discussion

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