Supplement Scholar
GH Secretagogue / Prokinetic

Relamorelin

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

Relamorelin. Ghrelin receptor agonist studied for diabetic gastroparesis and motility disorders.

How it works. Activates ghrelin receptors on gastric smooth muscle and the enteric nervous system, accelerating gastric emptying and improving motility.

What the research supports. 2 graded claims. Strongest: Targets a condition with few effective options (preclinical).

Hormonal impact. Effects on GH, Ghrelin signaling.

Side effects and interactions. 1 medication interaction listed. Serious: QT prolongation has not been a major signal.

Stacking. Pairs well with Diabetes regimen optimization. Avoid combining with Mechanical gastric outlet obstruction.

Common forms. Available as Subcutaneous injection.

Community. Experiences from people who have tried Relamorelin. Anecdotes are not medical advice.

Relamorelin. Ghrelin receptor agonist studied for diabetic gastroparesis and motility disorders.

Molecular structureC43H50N8O5S · 791.0 g/mol

What it is

Relamorelin is a synthetic ghrelin receptor (GHSR-1a) agonist developed primarily as a prokinetic for diabetic gastroparesis rather than for GH release.

Also called

RM-131

How it works

Activates ghrelin receptors on gastric smooth muscle and the enteric nervous system, accelerating gastric emptying and improving motility.

Pathways

  • GHSR-1a
  • Gastric smooth muscle contractility
  • Enteric nervous system

Effects

  • +Gastric emptying in diabetic gastroparesis supports
  • ↓Nausea, vomiting, and postprandial bloating decreases

What the research supports

Targets a condition with few effective optionspreclinical
Subcutaneous, short-course dosingpreclinical

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Hormonal impact

↑GHincreases
↑Ghrelin signalingincreases

Side effects & interactions

Common side effects

  • Hypoglycemia in diabetics
  • Headache

Serious

  • QT prolongation has not been a major signal

Medication interactions

Insulin and sulfonylureasmoderate

Glycemic adjustment required as gastric emptying changes.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Diabetes regimen optimizationFaster emptying changes insulin timing requirements.

Avoid combining

  • Mechanical gastric outlet obstructionProkinetic action is contraindicated.

Common forms

  • Subcutaneous injection

Discussion

Loading discussion…