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Metabolic / Amylin

Pramlintide

Also: Symlin

Synthetic amylin analog taken with mealtime insulin to blunt blood-sugar spikes after meals.

Discussion
Overview

What it is

Approved in 2005 for type 1 diabetes and insulin-treated type 2 diabetes. It replaces amylin, a hormone made alongside insulin that people with diabetes lack or make too little of.

Common forms

Injection before meals
Mechanism

How it works

Mimics amylin: slows stomach emptying, suppresses glucagon after meals and increases fullness.

Amylin receptor agonismSlower gastric emptyingPost-meal glucagon suppression
↓Post-meal glucose
↓Appetite

Hormonal impact

↓Glucagon
Evidence

What the research supports

Lowers post-meal glucose and HbA1c alongside insulinstrong
Modest weight lossmoderate
Safety

Side effects & interactions

Side effects

  • Nausea
  • Reduced appetite
  • Headache
  • Severe low blood sugar when combined with insulin (boxed warning) serious

Medications

  • InsulinsevereMealtime insulin is usually cut by about half when starting; severe low blood sugar risk.
  • Drugs that slow gut movement (anticholinergics)moderateFurther slows digestion.
Community

Discussion

Experiences from people who have tried Pramlintide. Anecdotes are not medical advice.

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