Supplement Scholar
Bioregulator

Pinealon

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

Pinealon. Russian pineal-derived tripeptide bioregulator studied for neuroprotection and cognitive aging.

How it works. Modulates gene expression in neuronal cells, supporting antioxidant defenses, mitochondrial function, and circadian regulation.

What the research supports. 2 graded claims. Strongest: Short, well-tolerated peptide (preclinical).

Hormonal impact. Effects on Melatonin rhythm, Oxidative stress markers.

Side effects and interactions. 0 medication interactions listed. Serious: Long-term safety not well-characterized outside Russian literature.

Stacking. Pairs well with Sleep hygiene and consistent light exposure. Avoid combining with Pregnancy and lactation.

Common forms. Available as Subcutaneous injection, Intranasal.

Community. Experiences from people who have tried Pinealon. Anecdotes are not medical advice.

Pinealon. Russian pineal-derived tripeptide bioregulator studied for neuroprotection and cognitive aging.

3-residue chainC15H26N6O8 · 418.40 g/mol

What it is

Pinealon is a short peptide bioregulator developed in Russia as a synthetic analog of pineal gland peptides.

Also called

Glu-Asp-Arg

How it works

Modulates gene expression in neuronal cells, supporting antioxidant defenses, mitochondrial function, and circadian regulation.

Pathways

  • Gene-expression modulation in neurons
  • Antioxidant enzyme upregulation
  • Circadian gene support

Effects

  • +Cognitive performance in older adults (reported) supports
  • +Neuronal resilience to oxidative stress supports

What the research supports

Short, well-tolerated peptidepreclinical
Multiple mechanisms in one moleculepreclinical

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Hormonal impact

=Melatonin rhythmstabilizes
↓Oxidative stress markersdecreases

Side effects & interactions

Common side effects

  • Minimal reported

Serious

  • Long-term safety not well-characterized outside Russian literature

No notable medication interactions listed.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Sleep hygiene and consistent light exposureCircadian effects amplify with behavioral support.

Avoid combining

  • Pregnancy and lactationInsufficient safety data.

Common forms

  • Subcutaneous injection
  • Intranasal

Discussion

Loading discussion…