SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Experimental/BioregulatorResearch peptide

Pinealon

aka Glu-Asp-Arg

Russian pineal-derived tripeptide bioregulator studied for neuroprotection and cognitive aging.

Educational explainer of a research peptide. Profiles in this section deliberately omit clinical-trial citations, dosing protocols, and purchase links. Not FDA-approved as a supplement; not a recommendation to use.

Overview

Pinealon is a short peptide bioregulator developed in Russia as a synthetic analog of pineal gland peptides.

Source
  • Synthesized in research settings
Forms
  • Subcutaneous injection
  • Intranasal

Mechanism of action

Modulates gene expression in neuronal cells, supporting antioxidant defenses, mitochondrial function, and circadian regulation.

Pathways
  • · Gene-expression modulation in neurons
  • · Antioxidant enzyme upregulation
  • · Circadian gene support

How it acts on the body

Pinealon is part of the Khavinson 'bioregulator' family — short peptides reported to directly influence gene transcription in specific tissues. The pineal-derived family is studied for cognitive aging, circadian stabilization, and oxidative stress.

Most evidence is Russian preclinical and small clinical work. Reported effects include improved attention and memory scores in older adults and reduced markers of oxidative stress in neuronal models.

Hormonal & endocrine impact

How this peptide is reported to shift specific hormones and signaling molecules. Directionality reflects research literature and preclinical models, not clinical prescribing data.

Projected hormonal trajectory
Illustrative curves derived from reported direction of effect. Not measured patient data.

Curves are schematic shapes (sigmoid for increases/decreases, damped oscillation for modulation/stabilization) anchored to a 100% baseline. They communicate direction and tempo of change reported in research literature — not absolute hormone concentrations.

Melatonin rhythmStabilizes
Reported normalization of circadian patterns in older adults.
Oxidative stress markersDecreases
Antioxidant enzyme upregulation.

Effects on the body

Supports
Cognitive performance in older adults (reported)
Supports
Neuronal resilience to oxidative stress

Organ system effects

Brain & CNS

Primary target.

Endocrine

Indirect circadian effects via pineal-related pathways.

Reported effects

Drawn from preclinical research, anecdote, and small-scale clinical observation. No evidence grades are assigned — most peptides on this page lack rigorous human trials.

  • Short, well-tolerated peptide
  • Multiple mechanisms in one molecule

Potential side effects

Common
  • · Minimal reported
Rare
  • · Mild injection-site reaction
Serious
  • · Long-term safety not well-characterized outside Russian literature

Drug interactions

No notable interactions reported.

Pairing context

Often combined with
  • Sleep hygiene and consistent light exposure
    Circadian effects amplify with behavioral support.
Avoid combining with
  • Pregnancy and lactation
    Insufficient safety data.
Important. Research peptides described here are not FDA-approved supplements. Supplement Scholar does not endorse, recommend, or link to any source for purchase. Consult a qualified clinician before considering any peptide therapy.