Nootropic / Mood

PE-22-28

Also: Spadin analog

Seven-amino-acid spadin analog that blocks the TREK-1 potassium channel; fast antidepressant-like effects in mice.

Discussion

Overview

What it is

Derived from spadin, a fragment of the sortilin propeptide. In rodents it produced antidepressant-like effects within days and increased new neuron growth in the hippocampus. No human trials.

Common forms

Intranasal or injection (research only)

Mechanism

How it works

Inhibits TREK-1 potassium channels, raising neuron excitability in mood circuits and promoting neurogenesis.

TREK-1 channel inhibitionHippocampal neurogenesisSerotonergic neuron firing

↑Hippocampal neurogenesis (mice)

~Mood-related neuron firing

Evidence

What the research supports

Rapid antidepressant-like effects in micepreclinical

Safety

Side effects & interactions

Side effects

Unknown in humans

Medications

AntidepressantsmoderateUnstudied combination; effects on mood circuits could add up.

Community

Discussion

Experiences from people who have tried PE-22-28. Anecdotes are not medical advice.

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