Supplement Scholar
Neuroendocrine

Octreotide

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

Octreotide. Long-acting somatostatin analog that suppresses growth hormone and gut hormones.

How it works. Binds somatostatin receptors (mainly SSTR2 and SSTR5), suppressing growth hormone, IGF-1, insulin, glucagon and gut hormone release.

What the research supports. 2 graded claims. Strongest: Lowers GH and IGF-1 in acromegaly (strong).

Hormonal impact. Effects on Growth hormone, IGF-1, Insulin, Glucagon.

Side effects and interactions. 3 medication interactions listed. Serious: Gallstones.

Common forms. Available as Injection, Monthly depot injection, Oral capsule (Mycapssa).

Community. Experiences from people who have tried Octreotide. Anecdotes are not medical advice.

Octreotide. Long-acting somatostatin analog that suppresses growth hormone and gut hormones.

Molecular structureC49H66N10O10S2 · 1019.2 g/mol

What it is

An eight-amino-acid ring peptide used for acromegaly, carcinoid syndrome and some types of gut bleeding. Available as injections, a monthly depot and an oral capsule.

Also called

SandostatinMycapssa

How it works

Binds somatostatin receptors (mainly SSTR2 and SSTR5), suppressing growth hormone, IGF-1, insulin, glucagon and gut hormone release.

Pathways

  • SSTR2 / SSTR5 agonism
  • Growth hormone suppression
  • Gut hormone suppression

Effects

  • ↓Growth hormone and IGF-1 decreases
  • ↓Hormone-driven diarrhea and flushing decreases

What the research supports

Lowers GH and IGF-1 in acromegalystrong
Controls carcinoid syndrome diarrhea and flushingstrong

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Hormonal impact

↓Growth hormonedecreases
↓IGF-1decreases
↓Insulindecreases
↓Glucagondecreases

Side effects & interactions

Common side effects

  • Loose stools
  • Abdominal pain
  • Injection-site pain

Serious

  • Gallstones
  • Slow heart rate
  • Blood-sugar swings

Medication interactions

Cyclosporinemoderate

Lowers cyclosporine absorption.

Insulin / diabetes drugsmoderate

Doses may need adjusting.

Beta-blockersmoderate

Added slowing of the heart rate.

Check any supplement–medication combination with your pharmacist before starting.

Common forms

  • Injection
  • Monthly depot injection
  • Oral capsule (Mycapssa)

Discussion

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