Supplement Scholar
Anxiolytic

N-Acetyl Selank

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

N-Acetyl Selank. Acetylated Selank variant with extended anxiolytic and immunomodulatory activity.

How it works. Modulates GABAergic and serotonergic tone, increases BDNF, and inhibits enkephalin degradation, producing anxiolysis without sedation.

What the research supports. 2 graded claims. Strongest: Non-sedating anxiolysis (preclinical).

Hormonal impact. Effects on GABA tone, BDNF, Cortisol response.

Side effects and interactions. 1 medication interaction listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Cognitive behavioral therapy. Avoid combining with Severe depression with suicidality requiring urgent care.

Common forms. Available as Intranasal, Subcutaneous.

Community. Experiences from people who have tried N-Acetyl Selank. Anecdotes are not medical advice.

N-Acetyl Selank. Acetylated Selank variant with extended anxiolytic and immunomodulatory activity.

Molecular structureC35H59N11O10 · 793.9 g/mol

What it is

An acetylated form of Selank, a Tuftsin-derived heptapeptide originally developed in Russia for generalized anxiety.

Also called

NA-Selank

How it works

Modulates GABAergic and serotonergic tone, increases BDNF, and inhibits enkephalin degradation, producing anxiolysis without sedation.

Pathways

  • GABA-A allosteric modulation
  • Enkephalinase inhibition
  • BDNF induction

Effects

  • ↓Generalized anxiety symptoms decreases
  • +Sleep quality without sedation supports

What the research supports

Non-sedating anxiolysispreclinical
No tolerance or withdrawal reportedpreclinical

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Hormonal impact

↑GABA toneincreases
↑BDNFincreases
↓Cortisol responsedecreases

Side effects & interactions

Common side effects

  • Mild nasal irritation with intranasal use

Medication interactions

Benzodiazepinesmoderate

Theoretical additive GABAergic effect.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Cognitive behavioral therapyAnxiolysis improves engagement with skills practice.

Avoid combining

  • Severe depression with suicidality requiring urgent careShould not delay evidence-based treatment.

Common forms

  • Intranasal
  • Subcutaneous

Discussion

Loading discussion…