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GH Secretagogue

Modified GRF(1-29)

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

Modified GRF(1-29). Short-acting GHRH analog without the DAC linker, producing pulsatile GH release.

How it works. Binds pituitary GHRH receptors to drive a brief, physiologic GH pulse that respects somatostatin feedback.

What the research supports. 2 graded claims. Strongest: Preserves physiologic GH pulsatility (preclinical).

Hormonal impact. Effects on GH, IGF-1, Somatostatin.

Side effects and interactions. 1 medication interaction listed. Serious: Carpal tunnel symptoms with chronic high-dose use.

Stacking. Pairs well with Ipamorelin or GHRP-2. Avoid combining with Active malignancy.

Common forms. Available as Subcutaneous injection.

Community. Experiences from people who have tried Modified GRF(1-29). Anecdotes are not medical advice.

Modified GRF(1-29). Short-acting GHRH analog without the DAC linker, producing pulsatile GH release.

29-residue chain

What it is

A tetra-substituted GHRH(1-29) analog that resists DPP-IV degradation but lacks the albumin-binding DAC linker of full CJC-1295, giving a half-life of ~30 minutes.

Also called

CJC-1295 no-DACMod GRF 1-29

How it works

Binds pituitary GHRH receptors to drive a brief, physiologic GH pulse that respects somatostatin feedback.

Pathways

  • GHRH receptor
  • cAMP-PKA
  • GH gene transcription

Effects

  • ↑Endogenous GH pulse amplitude increases
  • +Recovery and body composition over months supports

What the research supports

Preserves physiologic GH pulsatilitypreclinical
Lower IGF-1 ceiling than DAC variantspreclinical

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Hormonal impact

↑GHincreases
↑IGF-1increases
~Somatostatinmodulates

Side effects & interactions

Common side effects

  • Injection site flushing
  • Transient lightheadedness

Serious

  • Carpal tunnel symptoms with chronic high-dose use

Medication interactions

Glucocorticoidsmoderate

Blunt GH response.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Ipamorelin or GHRP-2Synergistic pulse via complementary receptors.

Avoid combining

  • Active malignancyGH/IGF-1 axis stimulation is contraindicated.

Common forms

  • Subcutaneous injection

Discussion

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