Supplement Scholar
Pigmentation

Melanotan II

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

Melanotan II. A non-selective melanocortin agonist studied for tanning and libido effects — with a notable side-effect profile.

How it works. Activates MC1R in skin (melanogenesis) and MC4R in the CNS (arousal, appetite suppression). Non-selectivity drives many of its side effects.

What the research supports. 3 graded claims. Strongest: Faster tanning response with less UV (preclinical).

Hormonal impact. Effects on Alpha-MSH signaling, Appetite (leptin axis), Sexual arousal (MC4R), Melanin (skin).

Side effects and interactions. 1 medication interaction listed. Serious: Reports of melanoma in case studies of heavy users — long-term risk is unclear.

Stacking. Pairs well with Sunscreen and dermatology monitoring. Avoid combining with History of melanoma, Numerous atypical moles.

Common forms. Available as Subcutaneous injection.

Community. Experiences from people who have tried Melanotan II. Anecdotes are not medical advice.

Melanotan II. A non-selective melanocortin agonist studied for tanning and libido effects — with a notable side-effect profile.

Molecular structureC50H69N15O9 · 1024.2 g/mol

What it is

Melanotan II is a synthetic analog of alpha-MSH that binds multiple melanocortin receptors, stimulating melanin production and central arousal pathways.

How it works

Activates MC1R in skin (melanogenesis) and MC4R in the CNS (arousal, appetite suppression). Non-selectivity drives many of its side effects.

Pathways

  • MC1R-mediated melanogenesis
  • MC4R-mediated arousal
  • MC3R/MC5R secondary effects

Effects

  • ↑Skin pigmentation increases
  • +Sexual arousal supports
  • ↓Appetite decreases

What the research supports

Faster tanning response with less UVpreclinical
Appetite reductionpreclinical
Anecdotal libido enhancementpreclinical

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Hormonal impact

↑Alpha-MSH signalingincreases
↓Appetite (leptin axis)decreases
↑Sexual arousal (MC4R)increases
↑Melanin (skin)increases

Side effects & interactions

Common side effects

  • Nausea
  • Facial flushing
  • Spontaneous erections

Serious

  • Reports of melanoma in case studies of heavy users — long-term risk is unclear

Medication interactions

Photosensitizing drugsmoderate

Increased pigmentation response may amplify reactions.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Sunscreen and dermatology monitoringMitigates known risks.

Avoid combining

  • History of melanomaAvoid stimulating melanocytes.
  • Numerous atypical molesRisk profile increases.

Common forms

  • Subcutaneous injection

Discussion

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