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Metabolic / Incretin

Mazdutide

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

Mazdutide. Once-weekly GLP-1 and glucagon dual agonist for weight loss, approved in China in 2025.

How it works. Activates GLP-1 receptors (appetite and insulin) and glucagon receptors (energy use and liver fat burning).

What the research supports. 2 graded claims. Strongest: Weight loss in adults with overweight or obesity (strong).

Hormonal impact. Effects on Insulin, Glucagon signaling.

Side effects and interactions. 1 medication interaction listed. Serious: Raised heart rate.

Stacking. Avoid combining with Other GLP-1 drugs.

Common forms. Available as Weekly injection.

Community. Experiences from people who have tried Mazdutide. Anecdotes are not medical advice.

Mazdutide. Once-weekly GLP-1 and glucagon dual agonist for weight loss, approved in China in 2025.

No single structureC207H317N45O65 · 4476 g/mol

What it is

Developed by Innovent and Eli Lilly. Phase 3 trials in Chinese adults showed double-digit percentage weight loss over 48 weeks, along with lower liver fat and blood pressure.

Also called

IBI362LY3305677

How it works

Activates GLP-1 receptors (appetite and insulin) and glucagon receptors (energy use and liver fat burning).

Pathways

  • GLP-1 receptor agonism
  • Glucagon receptor agonism
  • Hepatic fat oxidation

Effects

  • ↓Body weight decreases
  • ↓Liver fat decreases
  • ↓Appetite decreases

What the research supports

Weight loss in adults with overweight or obesitystrong
Reduces liver fatmoderate

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Hormonal impact

↑Insulinincreases
↑Glucagon signalingincreases

Side effects & interactions

Common side effects

  • Nausea
  • Diarrhea
  • Vomiting

Serious

  • Raised heart rate
  • Pancreatitis risk (class effect)

Medication interactions

Insulin / sulfonylureasmoderate

Higher risk of low blood sugar.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Avoid combining

  • Other GLP-1 drugsDuplicate therapy.

Common forms

  • Weekly injection

Discussion

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