Supplement Scholar
Diagnostic GH Secretagogue

Macimorelin

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

Macimorelin. Oral ghrelin agonist used as a diagnostic test for adult GH deficiency.

How it works. Stimulates a robust, predictable GH pulse used as a stimulation test for adult GHD.

What the research supports. 2 graded claims. Strongest: Oral, single-dose diagnostic (preclinical).

Hormonal impact. Effects on GH.

Side effects and interactions. 2 medication interactions listed. Serious: QT prolongation — caution with QT-prolonging drugs.

Stacking. Pairs well with Formal endocrinology evaluation. Avoid combining with Known long-QT syndrome.

Common forms. Available as Oral solution.

Community. Experiences from people who have tried Macimorelin. Anecdotes are not medical advice.

Macimorelin. Oral ghrelin agonist used as a diagnostic test for adult GH deficiency.

Molecular structureC26H30N6O3 · 474.6 g/mol

What it is

Macimorelin is an oral ghrelin receptor agonist approved as a diagnostic agent for adult growth hormone deficiency.

Also called

MacrilenAEZS-130

How it works

Stimulates a robust, predictable GH pulse used as a stimulation test for adult GHD.

Pathways

  • GHSR-1a
  • GH release

Effects

  • ↑Stimulated GH release for diagnostic testing increases

What the research supports

Oral, single-dose diagnosticpreclinical
Replaces more burdensome testspreclinical

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Hormonal impact

↑GHincreases

Side effects & interactions

Common side effects

  • Dysgeusia
  • Fatigue
  • Headache

Serious

  • QT prolongation — caution with QT-prolonging drugs

Medication interactions

QT-prolonging agentsmoderate

Class effect — avoid co-administration.

Strong CYP3A4 inducersmoderate

May reduce macimorelin exposure and invalidate test.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Formal endocrinology evaluationTest should be interpreted in clinical context.

Avoid combining

  • Known long-QT syndromeCardiac risk.

Common forms

  • Oral solution

Discussion

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