Supplement Scholar
Gut Barrier

Larazotide

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

Larazotide. Tight-junction regulator studied as an adjunct in celiac disease and intestinal permeability.

How it works. Antagonizes zonulin signaling at intestinal tight junctions, keeping them closed in response to gluten and other triggers.

What the research supports. 2 graded claims. Strongest: Symptom reduction in celiac patients with persistent reactivity (preclinical).

Hormonal impact. Effects on Zonulin signaling, Inflammatory cytokines.

Side effects and interactions. 0 medication interactions listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Gluten-free diet adherence. Avoid combining with Active intestinal infection requiring barrier permeability for clearance.

Common forms. Available as Oral capsule.

Community. Experiences from people who have tried Larazotide. Anecdotes are not medical advice.

Larazotide. Tight-junction regulator studied as an adjunct in celiac disease and intestinal permeability.

Molecular structureC32H55N9O10 · 725.8 g/mol

What it is

Larazotide is a synthetic octapeptide that acts on intestinal tight junctions to reduce paracellular permeability, mainly studied as an adjunct in celiac disease.

Also called

AT-1001

How it works

Antagonizes zonulin signaling at intestinal tight junctions, keeping them closed in response to gluten and other triggers.

Pathways

  • Zonulin antagonism
  • Tight-junction regulation (ZO-1, occludin)

Effects

  • +Intestinal barrier integrity supports
  • ↓Gluten-triggered symptom flares decreases

What the research supports

Symptom reduction in celiac patients with persistent reactivitypreclinical
Mechanism-targeted rather than symptomaticpreclinical

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Hormonal impact

↓Zonulin signalingdecreases
↓Inflammatory cytokinesdecreases

Side effects & interactions

Common side effects

  • Headache
  • Urinary tract symptoms

No notable medication interactions listed.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Gluten-free diet adherenceAdjunct, not replacement, for dietary control.

Avoid combining

  • Active intestinal infection requiring barrier permeability for clearanceMechanism opposes that process.

Common forms

  • Oral capsule

Discussion

Loading discussion…