Supplement Scholar
Anti-inflammatory

KPV

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

KPV. C-terminal tripeptide of alpha-MSH with anti-inflammatory effects in gut and skin.

How it works. Enters cells directly and interferes with NF-kB and inflammatory cytokine signaling; also displays antimicrobial activity at high local concentration.

What the research supports. 2 graded claims. Strongest: Anti-inflammatory without immunosuppression (preclinical).

Hormonal impact. Effects on TNF-alpha, IL-6, Alpha-MSH pigmentation signal.

Side effects and interactions. 0 medication interactions listed. Serious: Limited long-term human data.

Stacking. Pairs well with BPC-157. Avoid combining with Severe immunosuppression.

Common forms. Available as Oral capsule, Subcutaneous injection, Topical.

Community. Experiences from people who have tried KPV. Anecdotes are not medical advice.

KPV. C-terminal tripeptide of alpha-MSH with anti-inflammatory effects in gut and skin.

3-residue chain

What it is

KPV is the C-terminal tripeptide of alpha-MSH (alpha-melanocyte-stimulating hormone), retaining anti-inflammatory activity without pigmentation or appetite effects.

Also called

Lys-Pro-Val

How it works

Enters cells directly and interferes with NF-kB and inflammatory cytokine signaling; also displays antimicrobial activity at high local concentration.

Pathways

  • NF-kB suppression
  • TNF-alpha and IL-6 modulation
  • Direct antimicrobial action

Effects

  • ↓Local inflammation decreases
  • +Mucosal and skin healing supports
  • ⊘Bacterial growth at high local concentration inhibits

What the research supports

Anti-inflammatory without immunosuppressionpreclinical
No pigmentation or appetite effectpreclinical

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Hormonal impact

↓TNF-alphadecreases
↓IL-6decreases
=Alpha-MSH pigmentation signalstabilizes

Side effects & interactions

Common side effects

  • Mild injection-site reaction

Serious

  • Limited long-term human data

No notable medication interactions listed.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • BPC-157Complementary mucosal and tissue-repair effects.

Avoid combining

  • Severe immunosuppressionAnti-inflammatory layering may compound vulnerability.

Common forms

  • Oral capsule
  • Subcutaneous injection
  • Topical

Discussion

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