Supplement Scholar
Reproductive / HPG

Kisspeptin-10

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

Kisspeptin-10. Decapeptide fragment of kisspeptin that drives GnRH release and gates the reproductive axis.

How it works. Binds KISS1R (GPR54) on GnRH neurons, triggering GnRH release that drives LH and FSH from the pituitary.

What the research supports. 2 graded claims. Strongest: Physiological IVF trigger with lower OHSS risk (preclinical).

Hormonal impact. Effects on GnRH, LH, FSH, Testosterone / Estradiol.

Side effects and interactions. 1 medication interaction listed. Serious: Limited large-trial human data.

Stacking. Pairs well with Reproductive medicine specialist oversight. Avoid combining with Hormone-sensitive malignancy.

Common forms. Available as Subcutaneous or intravenous injection (clinical research).

Community. Experiences from people who have tried Kisspeptin-10. Anecdotes are not medical advice.

Kisspeptin-10. Decapeptide fragment of kisspeptin that drives GnRH release and gates the reproductive axis.

10-residue chainC63H83N17O14 · 1302.4 g/mol

What it is

Kisspeptin-10 is the active C-terminal fragment of kisspeptin, the hypothalamic peptide that controls GnRH neuron firing and therefore the entire HPG axis.

How it works

Binds KISS1R (GPR54) on GnRH neurons, triggering GnRH release that drives LH and FSH from the pituitary.

Pathways

  • KISS1R activation
  • GnRH release
  • LH/FSH pulse generation

Effects

  • ↑GnRH and gonadotropin pulses increases
  • +Physiological ovulation trigger supports
  • +HPG axis testing optimizes

What the research supports

Physiological IVF trigger with lower OHSS riskpreclinical
Diagnostic probe for HPG functionpreclinical

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Hormonal impact

↑GnRHincreases
↑LHincreases
↑FSHincreases
↑Testosterone / Estradiolincreases

Side effects & interactions

Common side effects

  • Flushing
  • Headache

Serious

  • Limited large-trial human data

Medication interactions

GnRH agonists or antagonistsmoderate

Direct mechanism overlap.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Reproductive medicine specialist oversightUsed in controlled IVF protocols.

Avoid combining

  • Hormone-sensitive malignancyActivates the entire steroidogenesis cascade.

Common forms

  • Subcutaneous or intravenous injection (clinical research)

Discussion

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