Supplement Scholar
GH Secretagogue

Hexarelin

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

Hexarelin. Potent GHRP with extra cardioprotective signaling via the CD36 receptor.

How it works. Binds GHS-R1a for GH release and CD36 in cardiac tissue, supporting contractility and limiting ischemic damage in animal models.

What the research supports. 2 graded claims. Strongest: Strong acute GH response (preclinical).

Hormonal impact. Effects on Growth hormone, Cortisol, Prolactin, IGF-1.

Side effects and interactions. 1 medication interaction listed. Serious: Pituitary desensitization with chronic use.

Stacking. Pairs well with Short cycle protocols. Avoid combining with Chronic daily dosing.

Common forms. Available as Subcutaneous injection, Intranasal (research).

Community. Experiences from people who have tried Hexarelin. Anecdotes are not medical advice.

Hexarelin. Potent GHRP with extra cardioprotective signaling via the CD36 receptor.

Molecular structureC47H58N12O6 · 887.0 g/mol

What it is

Hexarelin is a synthetic hexapeptide ghrelin-receptor agonist with the strongest acute GH response of the classic GHRPs and additional binding at CD36 in cardiac tissue.

How it works

Binds GHS-R1a for GH release and CD36 in cardiac tissue, supporting contractility and limiting ischemic damage in animal models.

Pathways

  • GHS-R1a
  • CD36 cardiac signaling

Effects

  • ↑GH pulse amplitude increases
  • +Cardiac contractility (preclinical) supports
  • ⊘Long-term natural GH pulsatility at high doses inhibits

What the research supports

Strong acute GH responsepreclinical
Cardiac signaling of research interestpreclinical

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Hormonal impact

↑Growth hormoneincreases
↑Cortisolincreases
↑Prolactinincreases
↑IGF-1increases

Side effects & interactions

Common side effects

  • Hunger
  • Flushing
  • Drowsiness

Serious

  • Pituitary desensitization with chronic use

Medication interactions

Other GH secretagoguesmoderate

Compounded HPA and desensitization risk.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Short cycle protocolsLimits desensitization.

Avoid combining

  • Chronic daily dosingBlunts the very response it was used to enhance.

Common forms

  • Subcutaneous injection
  • Intranasal (research)

Discussion

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