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Metabolic / GH Fragment

HGH Fragment 176-191

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

HGH Fragment 176-191. C-terminal GH fragment retaining lipolytic activity without GH or IGF-1 effects.

How it works. Stimulates β3-adrenergic-like lipolysis in adipocytes without binding the GH receptor or raising IGF-1.

What the research supports. 2 graded claims. Strongest: No IGF-1 elevation (preclinical).

Hormonal impact. Effects on GH receptor activity, IGF-1, Insulin sensitivity.

Side effects and interactions. 0 medication interactions listed. No serious side effects listed at normal doses.

Stacking. Pairs well with Caloric deficit and resistance training. Avoid combining with Severe cardiovascular disease.

Common forms. Available as Subcutaneous injection.

Community. Experiences from people who have tried HGH Fragment 176-191. Anecdotes are not medical advice.

HGH Fragment 176-191. C-terminal GH fragment retaining lipolytic activity without GH or IGF-1 effects.

Molecular structureC80H127N23O24S2 · 1859.1 g/mol

What it is

A synthetic fragment of the C-terminal 16 amino acids of human growth hormone, isolated to preserve fat-mobilizing activity while removing the somatogenic effects.

Also called

AOD analogLipolytic fragment

How it works

Stimulates β3-adrenergic-like lipolysis in adipocytes without binding the GH receptor or raising IGF-1.

Pathways

  • β3-adrenergic-like signaling
  • Hormone-sensitive lipase activation

Effects

  • ↑Adipocyte lipolysis increases
  • +Body composition without IGF-1 elevation supports

What the research supports

No IGF-1 elevationpreclinical
No blood glucose disruptionpreclinical

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Hormonal impact

~GH receptor activitymodulates
=IGF-1stabilizes
~Insulin sensitivitymodulates

Side effects & interactions

Common side effects

  • Injection-site reaction

No notable medication interactions listed.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Caloric deficit and resistance trainingLipolysis only matters if mobilized fat is oxidized.

Avoid combining

  • Severe cardiovascular diseaseAdrenergic-like lipolysis under-studied in this population.

Common forms

  • Subcutaneous injection

Discussion

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