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Longevity / Senolytic

FOXO4-DRI

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

FOXO4-DRI. Experimental peptide designed to make senescent ("zombie") cells self-destruct by blocking FOXO4 from binding p53.

How it works. Blocks the FOXO4–p53 interaction inside senescent cells, freeing p53 to trigger apoptosis in those cells while largely sparing healthy ones.

What the research supports. 1 graded claims. Strongest: Clears senescent cells and restores fitness in aged mice (preclinical).

Side effects and interactions. 0 medication interactions listed. No serious side effects listed at normal doses.

Common forms. Available as Injection (animal research only).

Community. Experiences from people who have tried FOXO4-DRI. Anecdotes are not medical advice.

FOXO4-DRI. Experimental peptide designed to make senescent ("zombie") cells self-destruct by blocking FOXO4 from binding p53.

No single structureC228H388N86O64 · 5358 g/mol

What it is

A D-retro-inverso peptide first reported in 2017. In aged and chemotherapy-treated mice it cleared senescent cells and improved fur density, fitness and kidney function. There are no published human trials.

Also called

Proxofim

How it works

Blocks the FOXO4–p53 interaction inside senescent cells, freeing p53 to trigger apoptosis in those cells while largely sparing healthy ones.

Pathways

  • FOXO4–p53 disruption
  • p53-driven apoptosis
  • Senescent cell clearance

Effects

  • ↓Senescent cell burden (mice) decreases

What the research supports

Clears senescent cells and restores fitness in aged micepreclinical

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Side effects & interactions

Common side effects

  • Unknown in humans

No notable medication interactions listed.

Check any supplement–medication combination with your pharmacist before starting.

Common forms

  • Injection (animal research only)

Discussion

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