Supplement Scholar
Sleep / Neuroendocrine

DSIP

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

DSIP. Nonapeptide originally isolated from sleeping rabbit brain, studied for sleep architecture and HPA stabilization.

How it works. Modulates HPA axis activity, melatonin secretion, and somatostatin tone in ways that favor consolidated sleep and stress-axis stabilization.

What the research supports. 2 graded claims. Strongest: Improved sleep onset and depth (preclinical).

Hormonal impact. Effects on Cortisol, Melatonin, GH, ACTH.

Side effects and interactions. 1 medication interaction listed. Serious: Limited large-trial data.

Stacking. Pairs well with Sleep hygiene. Avoid combining with Daytime dosing.

Common forms. Available as Subcutaneous injection, Intranasal.

Community. Experiences from people who have tried DSIP. Anecdotes are not medical advice.

DSIP. Nonapeptide originally isolated from sleeping rabbit brain, studied for sleep architecture and HPA stabilization.

9-residue chainC35H48N10O15 · 848.8 g/mol

What it is

DSIP is a nonapeptide first isolated from the cerebral venous blood of sleeping rabbits, named for its initial association with delta-wave sleep.

Also called

Delta Sleep-Inducing Peptide

How it works

Modulates HPA axis activity, melatonin secretion, and somatostatin tone in ways that favor consolidated sleep and stress-axis stabilization.

Pathways

  • HPA-axis modulation
  • Melatonin support
  • Somatostatin tone

Effects

  • +Sleep architecture supports
  • ↓Stress reactivity decreases
  • +HPA rhythm optimizes

What the research supports

Improved sleep onset and depthpreclinical
Calmer subjective stress responsepreclinical

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Hormonal impact

↓Cortisoldecreases
↑Melatoninincreases
~GHmodulates
↓ACTHdecreases

Side effects & interactions

Common side effects

  • Mild headache
  • Daytime drowsiness if mistimed

Serious

  • Limited large-trial data

Medication interactions

Sedativesminor

Additive drowsiness.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Sleep hygieneReinforces circadian alignment.

Avoid combining

  • Daytime dosingCan cause sedation if mistimed.

Common forms

  • Subcutaneous injection
  • Intranasal

Discussion

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