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Growth Hormone Secretagogues

CJC-1295 (no DAC)

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

CJC-1295 (no DAC). A modified GHRH analog that amplifies natural growth-hormone pulses without sustained suprapulse elevation.

How it works. Binds the GHRH receptor on the pituitary to stimulate growth-hormone synthesis and release; works synergistically with ghrelin-receptor peptides like ipamorelin.

What the research supports. 3 graded claims. Strongest: Amplifies natural GH pulses without prolonged elevations (preclinical).

Hormonal impact. Effects on Growth hormone, IGF-1, Somatostatin, Cortisol & prolactin.

Side effects and interactions. 1 medication interaction listed. Serious: Unknown long-term effects on IGF-1 and insulin sensitivity.

Stacking. Pairs well with Ipamorelin. Avoid combining with Active malignancy.

Common forms. Available as Subcutaneous injection.

Community. Experiences from people who have tried CJC-1295 (no DAC). Anecdotes are not medical advice.

CJC-1295 (no DAC). A modified GHRH analog that amplifies natural growth-hormone pulses without sustained suprapulse elevation.

29-residue chainC165H269N47O46 · 3647.2 g/mol

What it is

CJC-1295 without DAC (also called Mod GRF 1-29) is a short-acting GHRH analog with a half-life of about 30 minutes, designed to enhance pulsatile GH release.

Also called

Mod GRF 1-29

How it works

Binds the GHRH receptor on the pituitary to stimulate growth-hormone synthesis and release; works synergistically with ghrelin-receptor peptides like ipamorelin.

Pathways

  • GHRH-R → cAMP → GH transcription and release

Effects

  • ↑GH pulse amplitude increases
  • +Body composition and recovery supports

What the research supports

Amplifies natural GH pulses without prolonged elevationspreclinical
Often stacked with GHRPs for full somatotropic effectpreclinical
May improve sleep, recovery, and skin qualitypreclinical

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Hormonal impact

↑Growth hormoneincreases
↑IGF-1increases
~Somatostatinmodulates
=Cortisol & prolactinstabilizes

Side effects & interactions

Common side effects

  • Facial flushing
  • Injection-site reaction
  • Tingling

Serious

  • Unknown long-term effects on IGF-1 and insulin sensitivity

Medication interactions

Glucocorticoidsmoderate

May suppress GH response.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • IpamorelinClassic GHRH + GHRP research combination for synergistic pulses.

Avoid combining

  • Active malignancyGH/IGF-1 stimulation is generally avoided.

Common forms

  • Subcutaneous injection

Discussion

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