Supplement Scholar
GnRH Antagonist

Cetrorelix

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

Cetrorelix. GnRH receptor antagonist used to prevent premature ovulation in IVF cycles.

How it works. Competitively blocks pituitary GnRH receptors, rapidly suppressing LH and FSH release without an initial flare.

What the research supports. 2 graded claims. Strongest: No flare phase (preclinical).

Hormonal impact. Effects on LH, FSH, Estradiol.

Side effects and interactions. 0 medication interactions listed. Serious: Ovarian hyperstimulation syndrome from concurrent stimulation.

Stacking. Pairs well with Controlled ovarian stimulation protocols. Avoid combining with Known hypersensitivity to GnRH peptides.

Common forms. Available as Subcutaneous injection.

Community. Experiences from people who have tried Cetrorelix. Anecdotes are not medical advice.

Cetrorelix. GnRH receptor antagonist used to prevent premature ovulation in IVF cycles.

Molecular structureC70H92ClN17O14 · 1431.0 g/mol

What it is

Cetrorelix is a synthetic decapeptide GnRH receptor antagonist used as an injectable in assisted reproduction.

Also called

Cetrotide

How it works

Competitively blocks pituitary GnRH receptors, rapidly suppressing LH and FSH release without an initial flare.

Pathways

  • GnRH receptor antagonism
  • LH and FSH suppression

Effects

  • ⊘Premature LH surge during ovarian stimulation inhibits

What the research supports

No flare phasepreclinical
Rapid onset and offsetpreclinical

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Hormonal impact

↓LHdecreases
↓FSHdecreases
=Estradiolstabilizes

Side effects & interactions

Common side effects

  • Local injection-site reaction
  • Mild nausea

Serious

  • Ovarian hyperstimulation syndrome from concurrent stimulation

No notable medication interactions listed.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Controlled ovarian stimulation protocolsDesigned for that use.

Avoid combining

  • Known hypersensitivity to GnRH peptidesCross-reactivity risk.

Common forms

  • Subcutaneous injection

Discussion

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