Supplement Scholar
Neuropathy / Repair

ARA-290 (Cibinetide)

Also: Cibinetide · Helix B surface peptide

11-amino-acid peptide derived from erythropoietin that targets tissue repair without raising red blood cell counts.

Discussion
Overview

What it is

Designed to keep EPO's tissue-protective effect while avoiding its blood-thickening effect. Small phase 2 trials in sarcoidosis-related small-fiber neuropathy and in diabetic neuropathy reported less pain and more small nerve fibers.

Common forms

Subcutaneous injection (trials)
Mechanism

How it works

Activates the innate repair receptor, a pairing of the EPO receptor with CD131, which dampens inflammation and supports nerve repair.

Innate repair receptor (EPOR / CD131)Anti-inflammatory signalingSmall-fiber nerve regeneration
↓Neuropathic pain
+Small nerve fiber regrowth
↓Inflammation
Evidence

What the research supports

Reduces neuropathic pain in sarcoidosis small-fiber neuropathylimited
Increases corneal small nerve fiber densitylimited
Safety

Side effects & interactions

Side effects

  • Injection-site reactions
  • Headache
  • Long-term safety not established serious

Medications

  • No notable drug interactions listed.
Community

Discussion

Experiences from people who have tried ARA-290 (Cibinetide). Anecdotes are not medical advice.

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