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Fat Loss

AOD-9604

Research compound. This is not a dietary supplement. Unless it is identified as an approved prescription drug, it is not approved by the FDA for human use. This page summarizes published research for education only; we do not sell it or link to sellers.

AOD-9604. A fragment of human growth hormone studied for fat-burning effects without the broader anabolic actions of HGH.

How it works. Stimulates lipolysis and inhibits lipogenesis in adipocytes, reportedly without impacting IGF-1 or blood glucose like full HGH does.

What the research supports. 3 graded claims. Strongest: Targeted fat-burning without GH-related insulin effects (preclinical).

Hormonal impact. Effects on Growth hormone, IGF-1, Insulin sensitivity, Free fatty acids.

Side effects and interactions. 1 medication interaction listed. Serious: Human clinical efficacy has been modest; long-term safety is not fully characterized.

Stacking. Pairs well with Resistance training and caloric deficit. Avoid combining with Pregnancy.

Common forms. Available as Subcutaneous injection, Oral / sublingual (compounded, debated efficacy).

Community. Experiences from people who have tried AOD-9604. Anecdotes are not medical advice.

AOD-9604. A fragment of human growth hormone studied for fat-burning effects without the broader anabolic actions of HGH.

16-residue chainC78H123N23O23S2 · 1815.1 g/mol

What it is

AOD-9604 is a modified fragment (residues 176-191) of human growth hormone designed to retain HGH's lipolytic effects without its growth-promoting effects.

How it works

Stimulates lipolysis and inhibits lipogenesis in adipocytes, reportedly without impacting IGF-1 or blood glucose like full HGH does.

Pathways

  • Beta-3 adrenergic signaling (proposed)
  • Lipolysis in adipocytes
  • Lipogenesis inhibition

Effects

  • ↑Lipolysis in fat tissue increases
  • ↓Lipogenesis decreases
  • +Body recomposition (preclinical) supports

What the research supports

Targeted fat-burning without GH-related insulin effectspreclinical
Anecdotal reports of slow, steady body recompositionpreclinical
Investigated for joint and cartilage repair as an adjunctpreclinical

Strong: consistent results across large trials or meta-analyses. Moderate: several trials, mostly positive. Limited: small or mixed studies. Preclinical: animal or cell research only.

Hormonal impact

=Growth hormonestabilizes
=IGF-1stabilizes
=Insulin sensitivitystabilizes
↑Free fatty acidsincreases

Side effects & interactions

Common side effects

  • Injection-site reaction
  • Mild fatigue

Serious

  • Human clinical efficacy has been modest; long-term safety is not fully characterized

Medication interactions

Beta blockersminor

Theoretical antagonism of lipolytic pathway.

Check any supplement–medication combination with your pharmacist before starting.

Combines with

Pairs well

  • Resistance training and caloric deficitBest results when paired with lifestyle.

Avoid combining

  • PregnancyNo safety data.

Common forms

  • Subcutaneous injection
  • Oral / sublingual (compounded, debated efficacy)

Discussion

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