Bone

Abaloparatide

Also: Tymlos

PTHrP analog injection that builds bone in osteoporosis.

Discussion

Overview

What it is

A synthetic version of parathyroid hormone-related protein, approved for postmenopausal women and men at high fracture risk. Like teriparatide, it builds new bone rather than only slowing loss.

Common forms

Daily injection pen

Mechanism

How it works

Activates PTH1 receptors in a way that favors bone formation, with less rise in blood calcium than teriparatide.

PTH1 receptor agonismOsteoblast activation

↑Bone mineral density

↓Fracture risk

Hormonal impact

↑Calcium (blood)

Evidence

What the research supports

Reduces vertebral fractures (ACTIVE trial)strong

Reduces non-vertebral fracturesmoderate

Safety

Side effects & interactions

Side effects

Dizziness
Nausea
Palpitations
Dizziness or fainting on standing serious
High blood calcium serious

Medications

DigoxinmoderateHigh calcium can increase digoxin toxicity.

Stacking

Combines with

Pairs well

Calcium and vitamin DAdequate intake is needed for new bone.

Avoid combining

Nothing specific.

Community

Discussion

Experiences from people who have tried Abaloparatide. Anecdotes are not medical advice.

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